The Clinical Problem Solvers
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A Febrile Patient with an Abnormal ECG

Alec Rezigh, MD
Department of Medicine, Baylor College of Medicine
Stephanie Sherman, MD
Department of Medicine, Baylor College of Medicine
Zaven Sargsyan, MD
Department of Medicine, Baylor College of Medicine
Volume 1, Issue 1, pp. 13 | Published April 2026 | Submitted March 2026
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Abstract

A 60-year-old woman presented to the emergency department with two weeks of progressive malaise, anorexia, and fever. Evaluation revealed leukocytosis, thrombocytopenia, and acute kidney injury. Murine typhus was suspected and confirmed serologically. During a febrile episode, an ECG revealed a notable abnormality. Can you identify it?

Clinical Vignette

A 60-year-old woman presented to the emergency department with two weeks of progressive malaise, anorexia, and fever. Evaluation revealed leukocytosis, thrombocytopenia, and acute kidney injury. Murine typhus was suspected due to exposure to multiple animals and an absence of an alternative infectious syndrome. She received doxycycline empirically, and improved rapidly. Serologic results subsequently confirmed the diagnosis with a Rickettsia typhi IgM of >1:1024. During a febrile and tachycardic episode in the hospital, the patient's ECG showed the following (Figure 1):

What abnormality is present in this ECG?

References (1)
  1. 1. Brugada J, Campuzano O, Arbelo E, Sarquella-Brugada G, Brugada R. Present Status of Brugada Syndrome: JACC State-of-the-Art Review. J Am Coll Cardiol. 2018;72(9):1046-1059. doi:10.1016/j.jacc.2018.06.037

Conflict of Interest: The author(s) declare no conflict of interest.

Ethics Statement: The authors obtained verbal informed consent, witnessed and documented in accordance with institutional guidelines, for publication of medical information and images.

Correspondence: journal@clinicalproblemsolving.com

ORCID:Alec Rezigh, MD https://orcid.org/0000-0002-0820-6041

Keywords: ECG, Brugada pattern, fever, murine typhus, electrocardiography

A Febrile Patient with an Abnormal ECG | Journal of The Clinical Problem Solvers